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SCIENTIFIC ADVISORY BOARD
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Prof. Sir Andrew J MCMICHAEL
Member of the Scientific Advisory Board

Sir Andrew J MCMICHAEL is a Professor of Molecular Medicine at the Nuffield Department of Medicine at the University of Oxford, UK. He worked for more than 40 years on cytotoxic T-lymphocytes (CTL) responses against viruses, especially influenza

  • He first showed that human cytotoxic T lymphocyte (CTL) responses to influenza virus were HLA restricted and that these T cells could protect against disease (1977)
  • He showed that class I HLA molecules present influenza virus peptides to CTL with Alain Townsend (1986)

Expertise:
  • Identified the first epitopes seen by CTL in HIV-1 and then show that virus could escape from CTL by mutation, and later showed that this happens with all epitopes, undermining T cell control of the infection with Alain Townsend (1986)
  • Introduced HLA tetramers into the study of human infections, with Mark Davis and John Altman (1996)
  • Discovered CD1, with Cesar Milstein
  • Identified the ligand for the NK cell receptor NKG2/CD94 as a specific peptide bound HLA-E with Veronique Broad
  • Explored whether HLA-E restricted T cells are protective against HIV-1
  • Is working on HIV-1 vaccine development, harnessing CTL specific for highly conserved epitopes to control and possibly eradicate early infection

Prior Experience:
  • Professor of Molecular Medicine, Nuffield Department of Medicine, Oxford University, UK (1977 - present)
  • Fellowship with Dr Hugh McDevitt, Stanford University, US (1974-1976)

Award:
  • Knighthood for services to medical science (2008)
  • Nature/NESTA Award for Lifetime Mentoring (2006)
  • Ernst Chain Prize (2006)
  • Member of European Molecular Biology Organization (2004)
  • Novartis Prize (1998)
  • Fellow of the Academy of Medical Sciences (1998)
  • Fellow of the Royal Society (1992)

Education:
  • Medicine degree, University of Cambridge (1968)
  • PhD in Immunology at the MRC National Institute of Medical Research with Dr Ita Askonas (1971-1974)
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  • COMPANY
    • ABOUT US
    • EXECUTIVE COMMITTEE
    • SCIENTIFIC ADVISORY BOARD
    • CLINICAL ADVISORY BOARD
    • BOARD OF DIRECTORS
    • PARTNERS
  • SCIENCE
  • PIPELINE
    • OVERVIEW
    • INFLUENZA - OVX836
    • CORONAVIRUS
  • NEWS
    • PRESS RELEASES
    • MEDIA COVERAGE
    • PUBLICATIONS
    • EVENTS
  • CONTACT
    • LEGAL MENTIONS