Sir Andrew J MCMICHAEL is a Professor of Molecular Medicine at the Nuffield Department of Medicine at the University of Oxford, UK. He worked for more than 40 years on cytotoxic T-lymphocytes (CTL) responses against viruses, especially influenza
Expertise:
Prior Experience:
Award:
Education:
- He first showed that human cytotoxic T lymphocyte (CTL) responses to influenza virus were HLA restricted and that these T cells could protect against disease (1977)
- He showed that class I HLA molecules present influenza virus peptides to CTL with Alain Townsend (1986)
Expertise:
- Identified the first epitopes seen by CTL in HIV-1 and then show that virus could escape from CTL by mutation, and later showed that this happens with all epitopes, undermining T cell control of the infection with Alain Townsend (1986)
- Introduced HLA tetramers into the study of human infections, with Mark Davis and John Altman (1996)
- Discovered CD1, with Cesar Milstein
- Identified the ligand for the NK cell receptor NKG2/CD94 as a specific peptide bound HLA-E with Veronique Broad
- Explored whether HLA-E restricted T cells are protective against HIV-1
- Is working on HIV-1 vaccine development, harnessing CTL specific for highly conserved epitopes to control and possibly eradicate early infection
Prior Experience:
- Professor of Molecular Medicine, Nuffield Department of Medicine, Oxford University, UK (1977 - present)
- Fellowship with Dr Hugh McDevitt, Stanford University, US (1974-1976)
Award:
- Knighthood for services to medical science (2008)
- Nature/NESTA Award for Lifetime Mentoring (2006)
- Ernst Chain Prize (2006)
- Member of European Molecular Biology Organization (2004)
- Novartis Prize (1998)
- Fellow of the Academy of Medical Sciences (1998)
- Fellow of the Royal Society (1992)
Education:
- Medicine degree, University of Cambridge (1968)
- PhD in Immunology at the MRC National Institute of Medical Research with Dr Ita Askonas (1971-1974)