PUBLICATIONS |
Universal Influenza Vaccine Program
OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes. Judith Del Campo, Andres Pizzorno, Sophia Djebali, Julien Bouley, Marjorie Haller, Jimena Pérez-Vargas, Bruno Lina, Guy Boivin, Marie-Eve Hamelin, Florence Nicolas, Alexandre Le Vert, Yann Leverrier, Manuel Rosa-Calatrava, Jacqueline Marvel, Fergal Hill. 2019 Jan. doi: 10.1038/s41541-019-0098-4.
oligoDOM® (OVX313)
Minor capsid protein L2 polytope induces broad protection against oncogenic and mucosal human papillomaviruses. Pouyanfard S, Spagnoli G, Bulli L, Balz K, Yang F, Odenwald C, Seitz H, Mariz FC, Bolchi A, Ottonello S, Müller M. 2018 Feb. J Virol 92:e01930-17.
Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles. Gloria Spagnoli, Somayeh Pouyanfard, Davide Cavazzini, Elena Canali, Stefano Maggi, Massimo Tommasino, Angelo Bolchi, Martin Müller, Simone Ottonello. Sci Rep. 2017; 7: 18000. Published online 2017 Dec 21. doi: 10.1038/s41598-017-18177-1.
IMX313
Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology. Li Y, Leneghan DB, Miura K, Brian IJ, Dicks MD, Fyfe AJ, Zakutansky SE, De Cassan S, Long CA, Draper SJ, Hill AV, Hill F, Biswas S. Sci Rep. 2016 January 8;6:18848.
T Cell Responses Induced by Adenoviral Vectored Vaccines Can Be Adjuvanted by Fusion of Antigen to the Oligomerization Domain of C4b-Binding Protein. Emily K. Forbes, Simone C. de Cassan, David Llewellyn, Sumi Biswas, Anna L. Goodman, Matthew G. Cottingham, Carole A. Long, Richard J. Pleass, Adrian V. S. Hill, Fergal Hill, Simon J. Draper. PLoS ONE. 2012 September;7(9):e44943.
Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates. Spencer AJ, Hill F, Honeycutt JD, Cottingham MG, Bregu M, Rollier CS, Furze J, Draper SJ, Søgaard KC, Gilbert SC, Wyllie DH, Hill AVS. PLoS ONE. 2012 March;7(3): e33555. doi:10.1371/journal.pone.0033555.
Immunocontraception in male feral swine treated with a recombinant gonadotropin-releasing hormone vaccine. Tyler A. Campbell, PhD; Michelle R. Garcia, PhD; Lowell A. Miller, PhD; Martha A. Ramirez; David B. Long, MS; Jean-Baptiste Marchand, PhD; Fergal Hill, MB, BChir. JSHAP. May 2010; 18(3):118-124
The oligomerization domain of C4-binding protein (C4bp) acts as an adjuvant, and the fusion protein comprised of the 19-kilodalton merozoite surface protein 1 fused with the murine C4bp domain protects mice against malaria. Ogun SA, Dumon-Seignovert L, Marchand JB, Holder AA, Hill F. Infect Immun. 2008 Aug;76(8):3817-3823.
Effective induction of high-titer antibodies by viral vector vaccines. Draper SJ, Moore AC, Goodman AL, Long CA, Holder AA, Gilbert SC, Hill F, Hill AV. Nat Med. 2008 Aug;14(8):819-821.
OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes. Judith Del Campo, Andres Pizzorno, Sophia Djebali, Julien Bouley, Marjorie Haller, Jimena Pérez-Vargas, Bruno Lina, Guy Boivin, Marie-Eve Hamelin, Florence Nicolas, Alexandre Le Vert, Yann Leverrier, Manuel Rosa-Calatrava, Jacqueline Marvel, Fergal Hill. 2019 Jan. doi: 10.1038/s41541-019-0098-4.
oligoDOM® (OVX313)
Minor capsid protein L2 polytope induces broad protection against oncogenic and mucosal human papillomaviruses. Pouyanfard S, Spagnoli G, Bulli L, Balz K, Yang F, Odenwald C, Seitz H, Mariz FC, Bolchi A, Ottonello S, Müller M. 2018 Feb. J Virol 92:e01930-17.
Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles. Gloria Spagnoli, Somayeh Pouyanfard, Davide Cavazzini, Elena Canali, Stefano Maggi, Massimo Tommasino, Angelo Bolchi, Martin Müller, Simone Ottonello. Sci Rep. 2017; 7: 18000. Published online 2017 Dec 21. doi: 10.1038/s41598-017-18177-1.
IMX313
Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology. Li Y, Leneghan DB, Miura K, Brian IJ, Dicks MD, Fyfe AJ, Zakutansky SE, De Cassan S, Long CA, Draper SJ, Hill AV, Hill F, Biswas S. Sci Rep. 2016 January 8;6:18848.
T Cell Responses Induced by Adenoviral Vectored Vaccines Can Be Adjuvanted by Fusion of Antigen to the Oligomerization Domain of C4b-Binding Protein. Emily K. Forbes, Simone C. de Cassan, David Llewellyn, Sumi Biswas, Anna L. Goodman, Matthew G. Cottingham, Carole A. Long, Richard J. Pleass, Adrian V. S. Hill, Fergal Hill, Simon J. Draper. PLoS ONE. 2012 September;7(9):e44943.
Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates. Spencer AJ, Hill F, Honeycutt JD, Cottingham MG, Bregu M, Rollier CS, Furze J, Draper SJ, Søgaard KC, Gilbert SC, Wyllie DH, Hill AVS. PLoS ONE. 2012 March;7(3): e33555. doi:10.1371/journal.pone.0033555.
Immunocontraception in male feral swine treated with a recombinant gonadotropin-releasing hormone vaccine. Tyler A. Campbell, PhD; Michelle R. Garcia, PhD; Lowell A. Miller, PhD; Martha A. Ramirez; David B. Long, MS; Jean-Baptiste Marchand, PhD; Fergal Hill, MB, BChir. JSHAP. May 2010; 18(3):118-124
The oligomerization domain of C4-binding protein (C4bp) acts as an adjuvant, and the fusion protein comprised of the 19-kilodalton merozoite surface protein 1 fused with the murine C4bp domain protects mice against malaria. Ogun SA, Dumon-Seignovert L, Marchand JB, Holder AA, Hill F. Infect Immun. 2008 Aug;76(8):3817-3823.
Effective induction of high-titer antibodies by viral vector vaccines. Draper SJ, Moore AC, Goodman AL, Long CA, Holder AA, Gilbert SC, Hill F, Hill AV. Nat Med. 2008 Aug;14(8):819-821.